报告题目：Mechanisms and Programs of Neuronal Splicing Regulation
报告人： Douglas L. Black, Ph.D.
Investigator of the Howard Hughes Medical Institute
Professor of Microbiology, Immunology and Molecular Genetics, UCLA and David Geffen School of Medicine,
UCLAPresident, RNA Society
主持人： 肖睦 副教授
时 间： 2012年10月8日（星期一）上午10：00
地 点： 医学院综合楼205报告厅
Introduction of Speaker:
Education:
1987 Ph.D. Molecular Biophysics and Biochemistry,Yale University
1982 B.A. Chemistry , University of California at Santa Cruz
Editorial Board Member Journals:
Molecular and Cellular Biology, RNA, Genes and Development.
Research Interests:
The regulation of pre-mRNA splicing, particularly in neurons.
RNA metabolism in mammalian cells
Structure and function of pre-mRNP complexes
Selected Publications
1.Oberstrass FC, Auweter SD, Erat M, Hargous Y, Henning A, Wenter P, Reymond L, Amir-Ahmady B, Pitsch S, Black DL, Allain FH. “Structure of PTB bound to RNA: specific binding and implications for splicing regulation”. Science 309(5743):2054-7 (2005).
2.Lee JA, Tang ZZ, Black DL. “An inducible change in Fox-1/A2BP1 splicing modulates the alternative splicing of downstream neuronal target exons. Genes Dev 23(19):2284-93. (2009).
3.Shalini Sharma, Christophe Maris, Frédéric H-T Allain, and Douglas L. Black. “U1 snRNA Directly Interacts with Polypyrimidine Tract Binding Protein During Splicing Repression.” Molecular Cell 41(5):579-88. (2011).
4.Lauren T Gehman, Peter Stoilov, Jamie Maguire, Andrey Damianov, Chia-Ho Lin, Lily Shiue, Manuel Ares Jr, Istvan Mody & Douglas L Black, "The splicing regulator Fox-1 (A2BP1) controls neuronal excitation in the mammalian brain” Nature Genetics. 43(7):706-11. (2011).
5.Sika Zheng, Erin E. Gray, Geetanjali Chawla, Bo Torben Porse, Thomas J. O’Dell, & Douglas L. Black, “Psd-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2.” Nature Neuroscience. (2012) doi: 10.1038/nn.3026.
6.Bhatt DM, Pandya-Jones A, Tong AJ, Barozzi I, Lissner MM, Natoli G, Black DL, Smale ST. “Transcript dynamics of proinflammatory genes revealed by sequence analysis of subcellular RNA fractions.” Cell. 2012 Jul 20;150(2):279-90.
